Synthesis Process of Glufosinate Ammonium 2
In the ACA process invented by Bayer, the synthesis of MDP (N-phosphonomethyliminodiacetic acid) is extremely challenging. To bypass this step, Nissan Chemicals first invented the Strecker process for the production of glufosinate ammonium. This process has the advantage of being technically simple, with easily surmountable barriers, and suitable for large-scale production. In China, the majority of companies produce glufosinate ammonium using this technology. However, the process has some drawbacks. It involves high temperatures and pressures, making it prone to flammability and explosiveness, posing safety risks. Additionally, it generates a significant amount of industrial wastewater, exhaust gases, and residues, leading to substantial environmental impact.
Synthesis Method: Phosphorus trichloride, chloromethane, and aluminum trichloride are combined to produce MDP. MDP is then reacted with phosphorus oxychloride to form methylphosphonic dichloride. Subsequently, it is mixed with acrolein phosphate to generate phosphonic aldehyde. After undergoing the Strecker reaction, amino cyanide is formed. Following hydrolysis and purification, glufosinate ammonium is obtained.
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